CLONIDINE DEPENDENCE IN THE GUINEA-PIG ISOLATED ILEUM
نویسندگان
چکیده
منابع مشابه
Antihistaminic activity of carane derivatives in isolated guinea pig ileum.
Local anesthetics (LAs) inhibit membrane depolarization by reducing sodium and potassium conductance, and subsequent displacement of calcium ions from binding sites seems to occur. Histamine release appears to be a secretory process in which calcium couples the stimulus to the exocytosis of histamine-containing granules. Furthermore, LAs are structurally similar to histamine H(1)-receptor antag...
متن کاملPolar innervation of enteric non-cholinergic and non-adrenergic neurons in the isolated guinea-pig ileum.
To study the polarity of the efferent pathway of the myenteric plexus, recordings were made of the mechanical activity of the longitudinal muscle of isolated guinea-pig ileal segments upon stimulation with an electrical field around the myenteric plexus contained within strips of longitudinal muscle (LM-MP) continuous with each end of ileal segment. The amplitude of the contractile response to ...
متن کاملEvidence for A1 adenosine receptor–mediated inhibition of peristalsis in the guinea-pig isolated ileum
Segments of ileum (5-30 cm from the caecum) were obtained from male guinea-pigs (Dunkin Hartley, 300-500g), cannulated at the oral and aboral ends and secured horizontally in 10 ml baths containing Krebs’ solution maintained at 37oC and oxygenated with 95%O2 and 5%CO2. Regular peristalsis was obtained by infusing saline solution into the lumen using the method described previously (Costall et a...
متن کاملEffects of capsaicin on the circular muscle motility of the isolated guinea-pig ileum.
Effects of capsaicin on the circular muscle motility of the isolated guinea-pig ileum were investigated. Capsaicin produced a contraction followed by a relaxation of the circular muscle. Both responses were easily desensitized. As the late relaxation response was not sufficiently intense to be analyzed, the inhibitory effect of capsaicin on substance P-induced contractions was explored. Capsaic...
متن کاملOpiate-like inhibitory effect of trimebutine on the twitch response of the isolated guinea pig ileum.
Trimebutine at low concentrations (6 X 10(-9)-1.4 X 10(-8) M) slightly enhanced the twitch response of isolated guinea pig ileum induced by transmural stimulation. At high concentrations (2 X 10(-8)-2 X 10(-7) M), however, it inhibited the twitch response in a dose dependent manner. This inhibitory effect of trimebutine was reversed by naloxone (8.1 X 10(-9) M). These results suggest that trime...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1981
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1981.tb10441.x